- 题目：CGM 第190期: Epigenetic Reprogramming in Plant Germlines
- 时间：欧洲中部时间 2021 年 10 月 29 号（星期五）2PM（美国中部时间 2021 年 10 月 29 号7AM，北京时间 2021 年 10 月 29 号 8PM）
- 主讲人：冯小琦（Xiaoqi Feng）, University of Oxford ,PhD (2006-2010), UC Berkeley, Postdoc (2011-2014), John Innes Centre, Group Leader (2014- )
中文摘要
Germ cells are “immortal” as they can be indefinitely transmitted through generations. Establishment of germ cell immortality and identity requires extensive reprogramming of the chromatin state. Understanding this epigenetic reprogramming is crucial for the elucidation of germline biology. Conversely, germlines are essential for understanding epigenetics because they mediate inheritance and undergo large-scale epigenetic changes.
Feng lab established the Arabidopsis male germline – composed of four cell types produced by three sequential cell divisions – as a model system, and developed advanced techniques for cell isolation and epigenomic analysis. The ability to examine each germline cell type, combined with the high tolerance of Arabidopsis for epigenetic disruption, allows precise and powerful genetic analysis. Using this unique system, Feng lab aims to elucidate the scope, mechanism and biological significance of plant germline epigenetic reprogramming.
参考文献
Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Feng X. (2021) Nurse cell-derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science 373: eabh0556
He S, Vickers M, Zhang J, Feng X. (2019) Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation. eLife 8: e42530
Walker J, Gao H, Zhang J, Aldridge B, Vickers M, Higgins JD, Feng X. (2018) Sexual lineage specific DNA methylation regulates Arabidopsis meiosis. Nature Genetics 50: 130-137
Hsieh PH, He S, Buttress T, Gao H, Couchman M, Fischer RL, Zilberman D, Feng X. (2016) Arabidopsis male sexual lineage exhibits more robust maintenance of CG methylation than somatic tissues. PNAS 113: 15132-15137