- 题目：CGM 第148期: Systematic inference and comparison of multi-scale chromatin sub-compartments connects spatial organization to cell phenotypes
- 时间：欧洲中部时间 2021年4月8日（星期四）08PM（美国中部时间 4月8日 12PM，北京时间 4月9日 02AM）
- 主讲人：刘远龙（Yuanlong LIU），2010-2013：中国科学技术大学，概率论与数理统计，理学硕士；2013-2017：法国国家医学健康研究院（巴黎七大），计算基因组学 PhD，导师 Prof. Florence Dememais；2018-至今：计算基因组学 Postdoc, 导师 Prof. Giovanni Ciriello （瑞士洛桑大学)， Prof. Elisa Oricchio (瑞士洛桑联邦理工学院)
摘要
Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been characterized only in a few cell types and systematic comparisons across multiple tissues and conditions are missing. Here, we present Calder, an algorithmic approach that enables the identification of multi-scale sub-compartments at variable data resolution. Calder allows to infer and compare chromatin sub-compartments and compartment domains in >100 cell lines. Our results reveal sub-compartments enriched for poised chromatin states and undergoing spatial repositioning during lineage differentiation and oncogenic transformation.
参考文献
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Xiong, K., & Ma, J. (2019). Revealing Hi-C subcompartments by imputing inter-chromosomal chromatin interactions. Nature communications, 10(1), 1-12.