- 题目：比较基因组发现线虫控制性选择的新基因家族
- 时间：2018 年 07 月 11 号（星期三），美西时间（Pacific Time）6:00 PM
- 地点：YouTube live stream
- 主讲人：尹达 (Da Yin)(University of Maryland, College Park)
为了揭示生育模式对基因组的影响，我们比较了异交线虫Caenorhabditis nigoni与其自生
育近亲同胞物种C.briggsae的染色体。 C. nigoni的基因组类似于异交亲属，但蛋白质编码
基因比C. briggsae多31％。缺乏C. briggsae同源物基因的C. nigoni基因不成比例地偏小并
且在表达上具有雄性偏向。这些包括雄性分泌的短（mss）基因家族，仅表达在异交物种
中的精子表面糖蛋白。尽管在非竞争性交配中具有正常的生育能力，来自mss-null雄性C.
remanei的精子未能与野生型精子竞争。将mss恢复到C. briggsae雄性足以提高精子竞争
力。因此，性对基因组含量具有普遍影响，可用于鉴定精子竞争因子。
To reveal impacts of sexual mode on genome content, we compared chromosome-scale assemblies of the outcrossing nematode Caenorhabditis nigoni to its self-fertile sibling species, C. briggsae. C. nigoni’s genome resembles that of outcrossing relatives but encodes 31% more protein-coding genes than C. briggsae. C. nigoni genes lacking C. briggsae orthologs were disproportionately small and male-biased in expression. These include the male secreted short (mss) gene family, which encodes sperm surface glycoproteins conserved only in outcrossing species. Sperm from mss-null males of outcrossing C. remanei failed to compete with wild-type sperm, despite normal fertility in noncompetitive mating. Restoring mss to C. briggsae males was sufficient to enhance sperm competitiveness. Thus, sex has a pervasive influence on genome content that can be used to identify sperm competition factors.