- 题目：Phylogenetic approaches for quantifying interlocus gene conversion
- 时间：2018 年 05 月 30 号（星期三），美西时间（Pacific Time）6:00 PM
- 地点：YouTube live stream
- 主讲人：汲翔 (Xiang Ji) (Department of Biomath, University of California, Los Angeles)
位点间基因转换（IGC）使基因重复均质化。虽然基因组一般含有很多重复基因，但IGC对进化的重要性知之甚少，主要是由于缺乏统计工具。在本次报告中，我们总结了与IGC定量相关的系统发育建模策略。我们将首先介绍将IGC添加到广泛使用的序列变化概率模型中的策略。在14组酵母核糖体蛋白基因中，我们估计了源自IGC而不是点突变的密码子替换的百分比。我们发现比例从20％到38％不等。我们的结果与IGC在14个基因家族进化中的重要作用是一致的。
Interlocus gene conversion (IGC) homogenizes repeats. While genomes can be repeat-rich, the evolutionary importance of IGC is poorly understood, largely due to a lack of statistical tools. In this presentation, we summarize our phylogenetic modeling strategies related to the quantification of IGC. We will first introduce our strategy for adding IGC to widely-used probabilistic models for sequence change. In 14 groups of yeast ribosomal protein genes, we estimated the percentage of codon substitutions that originate with IGC rather than point mutation. We found values ranging from 20% to 38%. Our results are consistent with an important role for IGC in the evolution of each of the 14 gene families.